Follow @beeheron Ehlers-Danlos Syndrome and Autism Reading time: 8 minutes 15 seconds Summary A 2018 study found that a certain type of connective tissue cell called a myofibroblast was found in high quantities in the skin of people with hypermobility type EDS (hEDS), but not in other types of EDS. This cell is induced by [...]

Follow @beeheron Could Fisetin Be A New Treatment for ME/CFS and Autism? Reading time: 4 min 46 sec In my very first post on this site, I reported that I have a remarkable response to high dose biotin.  It reduces my ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) symptoms like severe fatigue and the mental confusion that people [...]

Follow @beeheron Low Blood Volume, ME/CFS and Slow, Chronic Sepsis Summary A very common cause of sepsis is the leakage of bacteria into the blood from the gut. ME/CFS patients have signs of leakage of bacteria from the gut into the blood and our illness looks a lot like sepsis. Low blood volume and mast [...]

Follow @Beeheron Mast Cell Activation Syndrome & Low Blood Volume Summary Two symptoms occur frequently in people with ME/CFS: Mast Cell Activation Syndrome (MCAS) and low blood volume. What if these are not coincidental? Reading time: 4 minutes 27 seconds People with ME/CFS have less blood than we should. We have low [...]

Follow @beeheron Shock, Hypoxia & ME/CFS: Part II Summary Numerous lines of evidence implicate problems with blood flow or oxygen delivery in ME/CFS. HIF-1 is the master regulator of the body's response to diminished oxygen delivery and is upregulated under low oxygen conditions. HIF-1 downregulates mitochondrial energy production and upregulates glycolysis in an effort to protect [...]

Follow @beeheron Shock, Hypoxia & ME/CFS: Part I When I first got sick with ME/CFS, I was a teenager. I was quite baffled when I suddenly became too exhausted to make it to classes, stopped sleeping almost entirely and started sweating profusely. I sweat raindrops: huge drops of sweat rolled down my sides constantly. No antiperspirant was [...]

Follow @beeheron Part II: ME/CFS, Sepsis and Glycocalyx Summary To recap from the previous blog post "Part I: Blood Flow in Sepsis & ME/CFS", ME/CFS looks like a lot like sepsis and sepsis is an inflammatory illness of blood vessels. The blood vessel problems in sepsis interfere with oxygen delivery to cells.   The particular kind of blood flow [...]

Follow @beeheron Part I: Blood Flow in Sepsis & ME/CFS Summary A blood flow pattern known as heterogeneous perfusion is found in sepsis. ME/CFS bears a striking resemblance to sepsis. We share peculiar problems with low blood volume, low blood pressure and trouble with pulling oxygen out of the blood to use as energy. [...]

On Autism & Chronic Fatigue Syndrome When I was in second grade, a little girl started calling me Weird One. I was elated. I felt that I had been knighted with some sort of public identity and it felt wonderful. I felt as though I belonged in some way and I hardly ever felt as though I [...]